Their wedding-night revelation — that Simone still has feelings for her ex, Trey — was a tired trope. The show will correct course by having them choose each other, but not without a cost. Lucas’s undiagnosed ADHD (heavily hinted at in S20) will be formally diagnosed, leading to medication and a reevaluation of his surgical skills. Simone, meanwhile, will discover she’s pregnant — not with Lucas’s child, but from a one-night stand with Trey right before the wedding. The ensuing arc will be about abortion, adoption, or single motherhood, handled with the nuance the show has earned.
Grey's Anatomy Season 21 premiered on , marking a return to a fuller 18-episode order following the strike-shortened Season 20. This season, which concluded on May 15, 2025 , balanced major character departures with the return of familiar faces from the franchise's history. Key Plot Points and Developments grey's anatomy season 21