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Despite the existence of modern versions like 1.20, the Eaglercraft community remains active for several distinct reasons:
Eaglercraft is a browser-based port of Minecraft Java Edition. It allows players to run a version of Minecraft directly in a web browser using WebAssembly and JavaScript—no actual Minecraft client or Java installation required.
Joining an Eaglercraft server is different from the traditional copy-paste IP method.
1.5.2 Eaglercraft servers represent a unique rebellion in the gaming world—a way to play a premium game for free, instantly, on any hardware. For players locked out of the official ecosystem or those yearning for the specific mechanics of the 1.5.2 era, these browser-based servers provide a digital sanctuary.
Unlike standard Minecraft servers that require a client-to-server TCP connection, Eaglercraft servers utilize .
Krasnov V.S.
Pavlov First St. Petersburg State Medical University
Kolontareva Yu.M.
Novartis Pharma LLC
Siponimod: a new view at the therapy of secondary progressive multiple sclerosis
Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry.
2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124
Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.
Pavlov First St. Petersburg State Medical University
Kolontareva Yu.M.
Novartis Pharma LLC
Received:
20.04.2021
Accepted:
04.06.2021
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Despite the existence of modern versions like 1.20, the Eaglercraft community remains active for several distinct reasons:
Eaglercraft is a browser-based port of Minecraft Java Edition. It allows players to run a version of Minecraft directly in a web browser using WebAssembly and JavaScript—no actual Minecraft client or Java installation required.
Joining an Eaglercraft server is different from the traditional copy-paste IP method.
1.5.2 Eaglercraft servers represent a unique rebellion in the gaming world—a way to play a premium game for free, instantly, on any hardware. For players locked out of the official ecosystem or those yearning for the specific mechanics of the 1.5.2 era, these browser-based servers provide a digital sanctuary.
Unlike standard Minecraft servers that require a client-to-server TCP connection, Eaglercraft servers utilize .
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