CTN readily crosses the blood‑brain barrier, achieving brain concentrations ~ 2‑fold higher than plasma at C max .
After 28 days of daily CTN (0.5 mg kg⁻¹), anxiolytic efficacy in the EPM the substance couchtuner
Couchtuner; phenethylamine; 5‑HT₂A antagonist; D₂ partial agonist; anxiolytic; cognition; drug development. CTN readily crosses the blood‑brain barrier