is a single nucleotide polymorphism (SNP) located in the oxytocin receptor (OXTR) gene on chromosome 3 (3p25.3). It is a transition mutation (G > A) found in the 3’ untranslated region (3’UTR) of the gene.

: While some DRD2 variants are linked to PD, meta-analyses have generally found that rs6278 does not show a significant association with the development of the disease.

: rs6278 is often studied as part of a 12kb haplotype block that spans both the DRD2 and ANKK1 genes.