Note: Season 3 was shortened due to the 2007–08 writers’ strike.

remains one of the most engaging and suspenseful thrillers in television history. From the iconic body-ink blueprints to high-stakes global conspiracies, here is your essential guide to every season and the standout episodes you can't miss. Season 1: The Fox River Breakout

The show revolves around two brothers, Michael Scofield (Wentworth Miller) and Lincoln Burrows (Dominic Purcell). Lincoln is accused of murdering the Vice President's brother and is sentenced to death row. Michael, a genius engineer, gets himself incarcerated in the same prison to help Lincoln escape.