Mediafire ((exclusive)) [ PREMIUM ]
Mostly, no. The ads are still there for free users, but they are less intrusive than they used to be. Free download speeds are capped, but they are comparable to the free tiers of Mega or Dropbox (around 1-2 MB/s).
The web interface is simple. You drag a file onto the browser window, it uploads, you copy the link. No confusing folder structures or syncing clients eating up your hard drive space. mediafire
The Definitive Guide to MediaFire: History, Features, and Cloud Storage Impact Mostly, no