Splitting - S1

This technique remains a valuable tool in the invasive cardiac electrophysiologist’s armamentarium for precisely localizing conduction abnormalities and guiding therapy.

Splitting occurs when the closure of the mitral and tricuspid valves is sufficiently asynchronous for the ear to perceive them separately. A split S1 is often best heard at the lower left sternal border (the tricuspid area). Normal (Physiological) Splitting splitting s1

Describe the S protein and its two main domains: S1 (binding) and S2 (fusion). This technique remains a valuable tool in the

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